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[Bad News] There is no mathematical formula available to calculate the number of structural isomers. You have to draw out all possible structures.
[Good News] There is a general approach for that.
APPROACH
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Draw the structure with the longest possible chain
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If a functional group is present, shift the position of the group to get all the different positional isomers
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After all positional isomers have been identified, draw the structure of the next longest chain (minus 1 C)
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Shift the position of the functional group and/ or substituent to get all the different isomers
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Repeat steps 3 & 4 until no more variations
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Example : Determine the number of structural isomers for C4H10Cl.
There are 4 structural isomers for C4H10Cl.